|
KMID : 0923620140140010014
|
|
Immune Network
2014 Volume.14 No. 1 p.14 ~ p.20
|
|
|
NF-κB Activation in T Helper 17 Cell Differentiation
|
|
Park Sang-Heon
Cho Ga-Bi
Park Sung-Gyoo
|
|
|
Abstract
|
|
|
|
CD28/T cell receptor ligation activates the NF-κB signaling cascade during CD4 T cell activation. NF-κB activation is re-quired for cytokine gene expression and activated T cell sur-vival and proliferation. Recently, many reports showed that NF-κB activation is also involved in T helper (Th) cell differ-entiation including Th17 cell differentiation. In this review, we discuss the current literature on NF-κB activation pathway and its effect on Th17 cell differentiation.
|
|
|
KEYWORD
|
|
|
NF-κB, Th17, T cell receptor, Autoimmune
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|